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Point mutations exist on at least 13 different amino acids distributed over the Abl-kinase domain, which make it difficult to overcome drug resistance.
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A spokeswoman for communications minister Mitch Fifield said the law passed in June is intended to assist copyright owners overcome jurisdictional barriers which make it difficult to enforce their rights against foreign-based infringing services online.
Although attempts have been made to engineer Clostridium in order to overcome these limitations [ 3, 5, 6], its complex physiology and lack of efficient genetic tools make it difficult to engineer [ 5].
These properties make it difficult to detect.
Make it difficult to do.
Make it difficult to cancel.
Make it difficult to watch porn.
Make it difficult to drink more.
This kind of thing can set a company back years, making it difficult to recruit and for staff members to overcome inertia internally.
The necessity of overcoming the traditionalism made it difficult to build oral health teams in Brazil.
Participants commented that the lack of incentive payments for involvement in shared records made it difficult to attract GPs to the system initially, but that the efficiency gains went some way to overcome this.
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