Sentence examples for make it difficult to formulate from inspiring English sources

However, the retrospective nature of most of the studies and the small sample sizes make it difficult to formulate a clinically useful prediction rules regarding allogeneic RBC transfusion.

The many variables which can be altered for an experiment, such as type, size, and concentration of ENMs, make it difficult to formulate generalizations about the uptake mechanism involved, or to make an inference on the subcellular localization and distribution of the internalized ENMs in plant tissue.

Despite the appropriateness of NoSQL and NewSQL data stores as cloud data management systems, the immense number of existing solutions (over 120 [10]) and the discrepancies among them make it difficult to formulate a perspective on the domain and even more challenging to select the appropriate solution for a problem at hand.

Contextual differences make it difficult to formulate strict rules that always give the 'correct' answer in a type of situation described on a general level.

However, many of these studies did not use large or representative samples, which make it difficult to formulate concrete conclusions that are representative of the complete population with hearing loss.

DOI: http://dx.doi.org/10.7554/eLife.02812.003 The relatively small number of spinal fMRI studies to date and lack of well-developed investigative tools make it difficult to formulate clear hypotheses of what low-frequency (< 0.08 Hz) BOLD signal correlations may be expected between sub-regions of spinal cord gray matter in a resting state.

Silymarin is poorly soluble both in water and oil, making it difficult to formulate as emulsion formulation, but it was successfully formulated as proliposomes with an improved bioavailability of 3.5-fold as against pure drug in beagle dogs.

This makes it difficult to formulate the operation regulation for train to train rescue.

However, unprecedented uncertainty exists in future scenarios making it difficult to formulate management planning paradigms.

Many of the included studies have methodological problems, and the quality of certain studies is low, making it difficult to formulate conclusive guidelines.

However, the complex dynamics that characterizes these devices makes it difficult to formulate control laws based on the MR damper model.