Sentence examples for make it difficult to extend from inspiring English sources

While naturally occurring mutations have demonstrated a central role for Oas in murine resistance to WNV infection, the radically different composition of the mammalian OAS gene clusters make it difficult to extend this conclusion.

The mountainous terrain and geographic features of El Hatillo have made it difficult to extend the Caracas Metro to southeast Caracas, so the main transportation methods in the municipality are private vehicles and road public transportation.

This "curse of dimension" makes it difficult to extend the present model to more species or more sequences.

Finally, it seemed odd that such a universal process as aging has such a specific driver, making it difficult to extend the theory to invertebrates (at that time).

However, aberrant cellular pH regulation is also a hallmark of many cancers (Harguindey et al., 2005), which makes it difficult to extend these conclusions to other cell types.

This makes it difficult to extend the training period, and in several countries the training course has been shortened [ 32], although this may adversely affect performance[ 23].

In some situations, trees, brush, or anything else that makes it difficult to extend a back cast may limit the movement of your cast.

The specifics of the implementation used in that case, however, make it difficult to directly extend the implementation to higher NA optics.

Ms. DeVore said she was told her remarks bordered on insubordination and would make it difficult to persuade the school board to extend her contract next year.

But extending the tax to derivatives is a messy business, because their complexities make it difficult to define precisely what should be taxed.

These properties make it difficult to detect.