Sentence examples for make it difficult to design from inspiring English sources

However, trypanothione reductase has structural similarity with its human homologue glutathione reductase, which could make it difficult to design selective analogues against this enzyme.

In this case various analytic constraints make it difficult to design a robust controller in the conventional manner (Isidori (1995)).

Such circumstance, along with the fact of the uncommon nature of the disease and the absence of clinically representative response criteria, make it difficult to design controlled clinical trials in SLE patients.

Here, we discuss possible artifacts and try to navigate through the many methods, preferences, and assumptions that surround protein localization in plants that make it difficult to design a universal approach to achieve reliable results.

Religious differences and tensions could make it difficult to design inclusive war memorials.

The large number of parameters and significant nonlinearities make it difficult to design an effective controller.

Its special characteristics have made it difficult to design instruments capable of performing a non-invasive evaluation of its structure and function in humans.

However, the high nonlinearity of the modulation sequences contained in q makes it difficult to design.

This complicated conformational transition issue makes it difficult to design optimum linkers for fusion proteins with multiple conformations.

Furthermore, the high order terms appear in a nonlocal operator, which makes it difficult to design an efficient implicit method.

Combined with the employment barriers it creates, the disability support system's fragmentation makes it difficult to design, test, and implement even modest employment innovations.