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The heterogeneity and tight coupling of modern critical infrastructures make it challenging to create tractable descriptions of their emergent behaviors.
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The complexity of this concept makes it challenging to create validated instrumentation for the evaluation of QoL after treatment.
But the things that make the play remarkable also make it challenging to produce.
The fact that PCV2 is extremely stable and is present globally creates opportunities for viral transmission, making it challenging to produce specific-pathogen-free animals.
Low-light situations make it challenging to select varieties that can adapt successfully.
But does the business model make it challenging to keep bad people from doing bad things?
This truncation can make it challenging to assess the shape of the ROC curve.
This can make it challenging to test between different therapies.
Other methodological changes between cycles make it challenging to compare data across NHANES cycles.
The short sequence reads produced make it challenging to identify indels from the sequence data.
Taken together, these can make it challenging to discuss deficits and improvements or develop shared standards.
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