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Pfizer is forging alliances left, right and centre, and is actively soliciting academics with bright ideas that would make good drugs.
These particular chemicals may or may not make good drugs, but the screening system proves, the researchers say, that it is possible to single out cancer stem cells with drugs that leave ordinary cells alone.
Worse, within six months it was evident that the complement blockers in the body worked only when they were attached to the surfaces of cells like chain mail armor, and would not make good drugs.
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For instance, he is looking for protein networks uniquely present in pathogenic organisms; these could make good drug targets.
They also hope to identify other genes and proteins involved in the splicing process they discovered, which could also make good drug targets.
The GlaxoSmithKline team, which looked just at a category of genes likely to make good drug targets, calculates that a rare variant occurs in one out of every 17 DNA units, of which the human genome has some three billion.
Even if only 10% of the human genome turns out to be responsible for proteins that would make good drug targets, that would multiply the inventory around sixfold.Turning this potential into medicines will take a lot of time and money.
Elledge cautions that this is just a start in determining which proteins might make good drug targets and that the technique won't pick up every one.
Can you make good drug arrests without having to use CIs? Yes, but it would be so much harder.
The inhibition of MAPK phosphorylation has been shown to decrease HIV infectivity, indicating that MA and Vif MAPK-directed phosphorylation events would make good drug targets [1], [2].
Such considerations are important not only for HIV drugs; trade agreements must include obligations to make good generic drugs available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com