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The phrase "make fundamental changes" is correct and usable in written English.
You can use it when referring to making changes that are very significant or drastic. For example: "We need to make fundamental changes to our business strategy if we want to be successful in the long run."
Exact(60)
These make fundamental changes to the processing method or layout.
Sierra Leoneans are being asked to make fundamental changes to their behaviour.
And at a time of war, you don't make fundamental changes like this.
If this is not good enough, the manager must make fundamental changes.
And if we don't make fundamental changes, it will happen all over again.
It will not be cured unless we make fundamental changes," he said.
And the Democratic National Committee will be under pressure to make fundamental changes.
But the next Congress and the next president will need to make fundamental changes.
And there are ample signs that the leadership is either unwilling or unable to make fundamental changes.
But there is less incentive for manufacturers to make fundamental changes in how buildings and roads are made.
Under pressure from Congress, both groups said that they would make fundamental changes in the way they do business.
More suggestions(15)
make significant changes
make major changes
make substantial changes
make substantive changes
make real changes
make deep changes
make far reaching changes
making fundamental changes
make basic changes
make slow changes
make fundamental adjustments
make simple changes
make final changes
make fundamental improvements
make fundamental decisions
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com