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Telomeric DNA recruits a number of different telomere-binding proteins to make functional telomeres.
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I got started because I wanted to make functional art.
I like making functional things that have a beautiful form.
For these reasons it is critical that functional telomeres do not stimulate the most powerful DDRs.
Thus, DM segregation did not seem dependent on binding to functional telomeres in human chromosomes.
The sum of these data indicates that Tel1-HAp associates with short functional telomeres while Mec1-HAp is recruited to dysfunctional telomeres.
The maintenance of functional telomeres is critical in that telomeres that become too short are unable to protect the chromosome from DNA damage.
Functional telomeres are essential for maintaining genome integrity; telomere shortening resulting from telomere dysfunction leads to genomic instability, which is a common cause and hallmark of cancer [ 29- 31].
This function is assisted by interacting proteins, generally referred to as the telosome, which are essential for functional telomeres [ 1].
Therefore, it is likely that shelterin provides an additional continuous mechanism for blocking Ku at functional telomeres.
Greider and Blackburn identified an enzyme, telomerase, that makes the telomeres.
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