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However, PC axons are present in the deep cerebellar nuclei several days before they make functional synapses when travelling waves may be most prevalent.
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This interaction is made possible by a shared panel of soluble and transmembrane molecules that transduce signals and form functional synapses between the two cell types [ 51, 52].
The collagen-entrapped NSCs/NPs recapitulate CNS stem cell development and form functional synapses and neuronal circuits.
Although silent synapses would be included in these decreased ones, some spines should form functional synapses (Harris and Stevens 1989; Noguchi et al. 2005).
Axons emerging from enteric ganglia crisscross the myenteric and submucosal plexuses and ultimately synapse onto neurons in other ganglia or make functional connections with extra-ganglionic tissues, such as smooth muscle, blood vessels and intestinal epithelium.
I got started because I wanted to make functional art.
I like making functional things that have a beautiful form.
For our experiments hippocampal neurons were kept in culture for more than 12 days when they have established functional synapses.
This suggests that PC axons may undergo refinement in the deep cerebellar nuclei after initial innervation but before functional synapses are made [ 51], and that this process might involve these travelling waves [ 6 ].
In other studies, areas with both presynaptic and postsynaptic proteins have revealed no functional synapses [ 83].
Furthermore, we have demonstrated functional synapse formation in the co-culture by immunocytochemistry and electrophysiological analysis.
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