I got started because I wanted to make functional art.
Thus, almost all clinical PET systems sold within the last years are combinations of PET and computed tomography (CT) systems, integrating the strengths of both modalities: the high specificity and sensitivity of PET making already functional changes in tissues visible at a very early stage of disease and the detailed morphologic information provided by CT [ 1].
I like making functional things that have a beautiful form.
Judgment of the role of cardiac TRPC channels is generally hampered by high variability of expression levels and by the fact that activation of TRPC conductances by (patho physiological stimuli is inevitably associated with parallel changes in phospholipid and Ca2+ signalling, which make clear assignment of functional changes to a TRPC conductance difficult.
This suggests that SSRs probably do not make a clear contribution to functional changes in pathogenicity factors, which allow P. infestans, P. sojae and P. ramorum to cause disease, but our study does not rule out the possibility that SSR polymorphisms may be present in pathogenicity genes.
However, elderly cancer patients often present with concomitant co-morbidities and age-associated physiologic problems, such as impaired organ function and functional changes that make the selection of optimal treatment difficult (Repetto and Balducci, 2002; Lichtman et al, 2007b).
For the SNPs for which the minor alleles is derived, functional changes made by rare exonic variants are stronger than those made by common variants.
However, post-mortem studies have insurmountable limitations: they do not allow making correlations between anatomical and functional changes during maturation and provide "region-specific" rather than "bundle-specific" information.
These biochemical properties make tetraspanins highly adaptable for functional changes.
Since ENCAPP uses differentially expressed modules between patients with good and bad prognosis to accurately predict disease outcome, the decision boundaries used to make this prediction correspond to functional changes in the cell.
