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The 'phosphorylated' eIF2 blocks protein production, which causes the cell to make fewer proteins.
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Those who slept less were actually making fewer proteins, the molecules that our bodies run on.
If a cell is stressed, such as by being exposed to harmful chemicals, it makes fewer proteins in order to conserve its resources.
For indirect assays (those that measure the effect of the miRNA, not the interaction itself), methodologies that rely on the detection of a protein make fewer assumptions about the predominant mode of action than those that rely on the detection of mRNAs.
When the miRNA binds to the gene expressing the red fluorescing protein, it is silenced, and the cell makes fewer red proteins compared to blue ones, whose production remains unhindered.
A recent study concluded that small molecule PPI modulators are larger (average molecular weight >400 Da), more hydrophobic (average alogP ∼4), with more aromatic rings (∼4 in average) and make fewer hydrogen bonds with the protein than average drugs [4].
Make fewer videos.
Would you make fewer loans?
It's very high in protein -- making it an option for vegans who have fewer protein options available to them, Gans says.
The smaller enthalpy change for 7 is consistent with making fewer interactions with the protein as would be expected for a smaller ligand.
One is that the proteins clump together, making fewer of them available for spinning.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com