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In either procedure, it is important to control for maternal effects and to recognize that genotype-by-environment interactions can make extrapolation to the natural environment difficult.
First, the number of participants is small and may not be representative, which might make extrapolation to all older dialysis patients less convincing.
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Previous reviews mostly described mid-term results making extrapolation to long-term results difficult.
However, optimum curing parameters have until now been specified in terms of a curing time for a specific recommended curing unit, making extrapolation to other curing units impossible.
Previous investigations have used transfected cells or transgenic mice engineered to express artificial PrP molecules in the cytosol, making extrapolation to physiological conditions difficult.
Furthermore, this study included 20 SCLC patients, which makes extrapolation to NSCLC patients difficult.
The geographic distribution of the available studies also makes extrapolation to the whole of Europe questionable.
Second, we conducted surveys only in districts where reactive vaccination campaigns were implemented, which makes extrapolation to the country difficult.
First, the number of patients included was small, which makes extrapolation to the total population of patients with PCI difficult.
Studies of the genotoxicity of PET bottled water have included plant species, such as Allium cepa (39) and Tradescantia (40) making extrapolation to human cells difficult.
The fundamental physical mechanisms underpinning plate tectonics, both in terms of its generation and maintenance over time, are not fully understood, which makes extrapolation to larger planets questionable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com