Exact(5)
With Ariad's system, the implanted genes do not switch on to make EPO until the patient takes a pill.
TKT says it can make EPO, which is used to treat anemia, in a manner that does not infringe Amgen's patents.
The production of EPO by means of recombinant techniques and its availability in various competent recombinant forms, make EPO an economical drug, conferring it as a potential candidate for enhancing fat transplantation without increasing considerably the cost of the procedure.
However, to make EPO cross the blood brain barrier (BBB) a brain penetrating form of human EPO has been developed.
To simulate the molecular adaptation of omptins, we applied site-specific mutagenesis to make Epo of the plant pathogenic Erwinia pyrifoliae exhibit virulence-associated functions of its close homolog, the plasminogen activator Pla of Yersinia pestis.
Similar(55)
The underlying mechanisms remain uncertain, but patients with certain malignancies may be in a hypercoagulable state, making EPO administration unadvisable.
To dissect out the contribution made by Epo to the signaling in PEPs, Epo-induced signaling should be analyzed under serum-free culture conditions to yield results unbiased by the poorly understood actions of other factors contained at variable concentrations in serum.
There are even reports that some tumors make their own Epo, in effect stimulating their own growth or protecting themselves from death.
Amgen, however, has five patents related to EPO that together claim to cover all versions of EPO made in cells of vertebrates.
Animal studies, for instance, have generally not shown Epo making cancer worse.
The strong association between the excision of the tubercle and the drop in Epo levels made us examine the granuloma for Epo expression.
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