Levetiracetam has a wide therapeutic window and predictable pharmacokinetics which make dosing convenient.
It is a major requirement to make dose-dense therapies feasible.
Physicians may have used guidelines other than the one we used in the study to make dose adjustments.
The clinical pharmacist did not make dose titrations for antihypertensive medications, instead recommendations were made in the medical record and the primary provider was alerted.
On the other hand, the hepatic route of elimination for linagliptin may make dose adjustment necessary in patients with hepatic failure.
In in vivo experiments, these agents were suspended in 0.5 w/v% methylcellulose 400cP solution (Wako Pure Chemical Industries, Osaka, Osaka, Japan) to make dosing formulations.
"We considered making Dose more mission-driven," he said.
Included in making dose assessments for the three CoP are calibration coefficients for a range of beam quality indices.
The study medication was also well-tolerated and it may be noted that the availability of the medicine in coated tablet form as well as in a liquid presentation (drops) makes dosing easy and convenient for young patients.
The absence of an MTD, of course, makes dose selection for phase 2 studies challenging.
This strategy makes dosing schedules easier to comply with and enhances efficacy.
