Furthermore, the difficulties in the design and in the interpretation of human intervention studies make difficult the establishment of a therapeutic index for flavonoids.
Notwithstanding the great progress made in the diagnosis and treatment of Müllerian adenosarcoma, its rarity and its heterogeneous behavior make difficult to set up well-defined therapeutic protocols.
Evaluation of therapeutic interventions for cellulite is made difficult by secondary confounding factors such as change of diet and exercise.
However, its use is made difficult by the wide interindividual variation in dose required to achieve a therapeutic effect, the narrow therapeutic range, and the risk of serious bleeding (Landefeld and Beyth 1993).
Short holes were made difficult.
The early kinetics of systemic TNF accumulation in sepsis makes it a difficult therapeutic target in clinical settings (Ref. 17), prompting a search for other, late pro-inflammatory mediators that may offer a wider therapeutic window.
Of note, in clinical practice, some 'disturbing factors', such as the reduced adherence to chronic therapies, make therapeutic goals difficult to achieve. 1 The availability of computerised health databases contributes decisively to observational studies of the impact of medications.
Resistance to chemotherapy is well known to make chondrosarcoma therapeutic management difficult [4].
In particular, the avoidant [ 66- 68, 79, 141] and narcissistic [ 76] personality traits of AN patients, in addition to their disadaptive management of anger [ 142, 143], make the therapeutic alliance difficult, sometimes enhancing the illness and patient's relational isolation.
