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However, the reduced risk must be confirmed before clinicians can make definite recommendations to women at risk for breast cancer.
Therefore, it is difficult to make definite recommendations on the comparative effectiveness and cost-effectiveness of different interventions in different stages of the medicines pathway.
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As the data are restricted to case reports, it is not feasible to draw definite recommendations.
While their study did not make any definite recommendation, it provided a wide perspective on how genetic variation is distributed among peripheral and more variable breeds, which can be helpful for decision-makers to carry out conservation programs.
Mr. Dupuy has not made definite plans for the future.
From that study, it was concluded that the potential of ultrasound in this specific context should be developed further before definite recommendations could be made.
However, as with those that were shown to be effective, the evidence of the effectiveness of these strategies is very limited, with additional and larger trials incorporating them into their design necessary to allow definite recommendations to be made.
Definite recommendations can only be made when the results of large randomised trials such as Japan Clinical Oncology Group (JCOG) 0802 in Japan, CALGB 140503 in North America and European Institute of Oncology IEOO) S638/311 in Italy become available.
For the majority of patients discussed at MDT meetings there was clear evidence of a definite recommendation being made: for only 31/513 (6.0 %) of discussions was it impossible to identify a recommendation.
Therefore, until a study of statins is performed that evaluates the effects on fracture reduction in patients with osteoporosis, definite recommendations of statin for bone health cannot be made.
Definite recommendations on anti SARS-CoV anti SARS-CoVompounds in humactivityofly be made in the in vivo setting.
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