However, in countries where the diabetic population is fairly adequately treated, the small improvement in QALYs will make cost-effectiveness less likely, even with less costly interventions.
Such proposals could include patient co-payment rises, means-tested co-payments, medicines savings accounts, changes to reference pricing, to the pricing of generic pharmaceuticals, or a diminution of the capacity of the PBAC to make cost-effectiveness recommendations[ 14].
Since option A at the time of the study was not being implemented at the study site, they did not make cost-effectiveness comparisons of option A and B relative to sd-NVP.
Building on these observations, we argue that taking time into account in economic evaluations (1) will make cost-effectiveness outcomes more realistic, and (2) could mean a step forward in bridging the gap between societal and local decision making, thereby making cost-effectiveness outcomes more useful for all kinds of decision makers.
Third, certain aspects of our diagnostic algorithm may not be standard practice in other settings, making cost-effectiveness estimates more difficult to translate to local conditions.
In addition, we could obtain the costs derived from each disease-related item separately, which may be useful when establishing adequate therapeutic strategies and making cost-effectiveness analyses.
However, for the remaining indicators there were insufficient data to make a clear link with health benefits, making cost-effectiveness analysis speculative.
Making cost-effectiveness comparisons across available first-line chemotherapy treatments is limited by the comparability of the treatment populations and the short time frames.
An increase in health care expenditure in cancer care makes cost-effectiveness analysis an important tool for national health care payers.
These probabilities are presented as cost-effectiveness acceptability curves [ 19] and a judgement made cost-effectiveness on the basis of maximum willingness to pay threshold of £20,000 per QALY, (lower boundary of acceptable cost effectiveness of the National Institute for Health and Clinical Excellence) [ 15, 26].
