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With the availability of vast genome sequence data from so many species of bacteria it has become possible to make comparative sequence analyses, to add further value to the work carried out with model bacteria such as E. coli and N. meningitidis.
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Such a complete genome analysis is only possible through re-sequencing, and in particular, through the next-generation sequencing technologies that make comparative genome sequencing feasible.
With the growing number of genome sequences, we can expect to get more sequences for obligate intracellular and free-living bacteria in all phyla, in order to make comparative genomic analyses including phyla remaining unstudied to date.
The availability of several whole genome sequences makes comparative analyses possible.
The plummeting cost of genome sequencing is making comparative genomics an attractive technique, and creative bioinoformatic methods which take advantage of targeted sequencing are becoming more prevalent [ 14- 16].
The increasing availability of multiple genome sequences has made comparative genomic analyses of P. aeruginosa possible.
As the entire genome sequence of P. falciparum is available and the macronuclear sequencing project of T. thermophila was just recently completed, we made comparative BLAST analyses against both genome sequences.
The islands of sequence in CM0113 are separated by gaps represented by 100 unattributed nucleotides (Ns), which makes comparative analysis between the two species difficult.
Regulatory networks are known to evolve quickly and both the DNA-binding domains of transcription factors and their target sequence sets are highly dynamic (i.e., orthologous regulators are often regulating non-orthologous targets), making comparative studies difficult [ 43, 44].
It made comparative analysis among these maps difficulty, therefore, an integrated melon map combining eight linkage maps was constructed using common simple sequence repeat (SSR) markers as anchor points (Diaz et al. 2011).
The infrequency of femoral head fractures makes comparative studies difficult.
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