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Second, two residues in PIR1 P-loop, H154 and N157, make close side chain contacts with the active site phosphate (postulated to exemplify RNA γ-phosphate), stabilizing this ion in the deep active site pocket.
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The other water could make a hydrogen bond with the O atom of Gly-179 but would make close contacts (3.0 3.1 Å) with side chains of Ser-183 (CB), Ala-207, and Phe-226.
The side chains of these residues make close contacts with a panel of hydrophobic amino acids, including V84, F87, Y124, V125, and I127 of DAXX (Fig. 2A).
In normal FOXP3, the side chain of arginine 337 is predicted to make close contact with the DNA backbone (Fig. 3 A, top panel).
Make close friends.
Make close friends with guys.
Both sides make closing arguments.
Although not oriented optimally for hydrophobic contacts, the side chain of F313 makes close contacts on one side of the galactose, whereas the side chain of L371 makes probable hydrophobic contacts on the other side (C6 methylene protons).
Both sides will make closing arguments on Thursday afternoon, then the jury will deliberate one last time.
The defense was deciding whether to call another witness on Tuesday, before both sides are expected to make closing arguments.
When making close calls, he tended to side with the accountability hawks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com