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We then used the imputed data to make clinical outcome predictions with the published models, and the results were compared with the predictions made using the complete test data with no missing data.
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3 14 15 There is also agreement that the heterogeneous nature of tinnitus symptoms and impact can also make clinical research and outcome measurement difficult.
Managing to regulatory outcome is the antithesis of patient outcome as the regulations were designed without clear clinical outcome corollaries.
This will create clinical outcome measures and biomarkers for clinical trial readiness, necessary to show effect of any experimental therapy.
Coagulation markers in the circulation have been shown to increase in patients hospitalized with CAP, although no correlations were made with clinical outcome (28, 34).
The informations derived on mucinous histology may help researchers and practitioners in designing future studies (e.g., stratification of patients according to the mucinous histology) and in making clinical decisions that will improve the outcome of patients with such histological type.
However, little is known about the effects of this "double paradigm shift" [ 16] toward global CVR and shared decision making on clinical outcomes.
These studies were designed to explore mechanisms of drug-DNA interactions, to make correlations with clinical outcome, and possibly to validate DNA adduct measurements for use in occupational and environmental biomonitoring.
However, this assumption may not reflect the true biological process; therefore, if the main interest is to make predictions about clinical outcome, then more general forms of functions (e.g. non-parametric functions) may need to be considered.
However, no correlation was made with the clinical outcome.
Thus so far, the diagnosis has primarily been made based on clinical outcome or serology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com