Sentence examples for make cilia and from inspiring English sources

Our analysis suggests that the key function on evolutionary time scales of Pix, and more importantly centrioles, is to make cilia and flagella.

Thus Pix proteins act as a weathervane to indicate changes in centriole function, whose core activity is to make cilia and flagella.

Moreover, this survey raises the possibility that Pix proteins are only maintained to make cilia and flagella that undulate, and even then only when they are constructed by transporting ciliary constituents up the cilium using the intraflagellar transport (IFT) system.

If one considers the maintenance of Pix proteins over evolutionary time scales, our analysis would suggest that their key function is to make cilia and flagella, and the same is true of centrioles.

Further, the Pix proteins themselves are only needed to make cilia and flagella that undulate, and even then only when (as is generally the case) they are constructed by transporting ciliary constituents up the cilium using the intraflagella transport (IFT) system.

MEFs derived from Ift88 or Ift172 embryos do not make cilia (Figure 4A) [28].

Similarly, mouse mutants that lack IFT complex B proteins IFT172 or IFT88 do not make cilia [3], [21], [22].

Although Kif3a −/− MEFs do not make cilia (Chen et al., 2011), Ptch1-GFP could still proceed to late endosomes/lysosomes under the influence of ShhN unabatedly, implying that Ptch1 endocytosis is downstream from or independent of ciliary trafficking.

Knockdown of NXN causes fewer cells to have cilia, and the cells that do have cilia, display short cilia.

We then scored animals for organ position (Fig. 1A), not pitx2 expression as in other studies (Beyer et al., 2012), because incidence of incorrect asymmetric gene expression strongly overestimates the effects of treatments on randomizing organ situs, making cilia-targeting treatments appear more penetrant than they are (supplementary material Fig. S1) (Vandenberg, 2012).

This suggests that the principal conserved function of centrioles is to make undulatory cilia or flagella, and of Pix is to enable centrioles to achieve this function.