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Over time, these genetic changes accumulate and can make cells more prone to the skin cancer melanoma.
To avoid confusion with radiosensitizing drugs, those compounds that make cells more sensitive to radiation, such as DNA repair inhibitors, oxygen transporters [see for instance (Lawrence et al. 2003)], in this review, we use the term "nano-radio-enhancers" (NRE) to distinguish these compounds.
According to Dr. Eric Mou, an Oncology Fellow Physician at Stanford Health Care, BRCA2 normally cuts down on genetic irregularities that make cells more prone to behaving abnormally.
Therefore, although in other cell systems like MEFs, [17], [21], [33] it seems to be indispensable the loss of at least one tumor suppressor to make cells more susceptible to Ras-induced hyper-replication effects.
This decreased peroxidizability may make cells more resilient to oxidative stress.
It is known that Bad modifications, which interfere with Bad phosphorylation, can make cells more or less sensitive to apoptosis.
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Adiponectin makes cells more responsive to insulin.
Rosiglitazone, which makes cells more sensitive to insulin, has been used for more than five years to treat people who have Type 2 diabetes, but this is the first time it has been studied on a large scale to prevent the disease.
Oxidative stress accumulates during aging which makes cells more prone to DNA damage.
Depletion of intracellular GSH by buthionine sulfoximine makes cells more susceptible to Cd2+-induced apoptosis.
Although researchers verified that the molecule slows down AIDS, they also discovered that it makes cells more likely to invite in HIV in the first place.
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