Sentence examples for make binding sites from inspiring English sources

To reduce the distortion introduced by sequencing bias or abundant RNA, normalization is recommended to make binding sites across the full transcriptome comparable [ 41].

This makes binding sites attractive targets for drug therapies, including anticancer chemotherapy.

Examination of the accumulative time of contact of the residues associated with binding sites I and II reveals that from all residues making binding site I, only E17, and to a lesser extant Q22, were sufficiently attractive to retain the ion for 14% and 7% of the total simulation time, respectively.

The large gigapores also make the binding sites on the diffusion pore surfaces more accessible, thus increasing the loading capacity of large protein molecules that can be hindered sterically if only diffusion pores are present.

To make the binding sites comparable and the data integrative across multiple samples from different batches, we used uniform pre-processing and peak-calling procedures to identify RBP binding sites from raw CLIP-seq data.

Evidently, the 300 mM KCl makes the binding sites in the RNA more accessible.

Incubation with BSA after actin binding blocks the surface making the binding sites on the side of actin rather inaccessible in contrast to those at the top.

Second, the short-life of protein chromatin interactions continuously makes available binding sites which can then be scanned by diffusing transcription factors.

These limitations make general binding site analysis with template-based methods difficult.

ATP-dependent chromatin-remodeling complexes (RCS) are specialized multi-protein complexes that use ATP to regulate gene expression by modulating the distribution of nucleosomes on DNA to make DNA-binding sites accessible to transcription factors, which can bind to DNA only when this is free from the nucleosome core.

This was partly based on the power of transcription-factor-discovery-motif algorithms that, when coupled to cross-species genome comparisons or phylogenetic footprinting, have proven successful in making reliable binding site predictions [ 39– 42].