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We could make agents less important.
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Restrictions first placed on the bureau in the 1970's still affect the organization, and make its agents less willing to take aggressive action.
However, the affects of ARBs on TGF-β protein expression are indirect and do not appear to translate to bone [ 21], thus making these agents less attractive for orthopaedic applications.
It is possible that this relative protease susceptibility may make the agent less robust in field conditions and thereby reduce the extent to which it is transmissible by natural routes, and so limit the number of cases.
In the brain, intravenous alpha-2 agonist (xylazine) resulted also in a decreased ICP, making this agent less interesting for the dual, systemic treatment of POAG/NTG.
The prolonged use of fusidic acid as topical monotherapy for chronic skin conditions appears to have resulted in the emergence of resistance among S. aureus isolates in some countries [ 35, 36], making this agent less active both for topical and systemic therapy [ 35].
This makes these tamponade agents less useful for closing inferior retinal breaks and for defending them from the proliferative vitreoretinopathy (PVR) that usually begins in the inferior quadrants.
"They made Agent Orange.
This can be accomplished by reducing the strength of selection [e.g. by making the selective agent less discriminating among genotypes, (Baskett et al. 2005) or by interfering with the population's ability to respond to a given selection pressure].
These more selective inhibitors reduce some of the dose-limiting side effects that made the first generation of less selective agents less successful than first anticipated [6].
Having long-term care insurance — agents, sharpen your pencils — made parents less likely to move closer, apparently because "it shows potentially less need for family care," Dr. Engelman hypothesized.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com