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There are many ways to make a virus.
To prove these guys wrong, we needed to make a virus that is transmissible".
By doing so, they virtually guaranteed they would make a virus that could pass between mammals.And so it proved.
All the pandemic viruses of the last century — the 1918, 1957 and 1968 flus — had a mutation in the gene coding for a protein known as PB1-F2 that is thought to make a virus more lethal.
But genetic changes that affect transmissibility do not necessarily change the properties that make a virus susceptible to drugs or to the antibodies produced by a vaccine, so that approach may not yield much useful new information.
For one, the changes that make a virus resistant to oseltamivir may make it less pathogenic, he says.
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How do you make a virus-free flu vaccine?
There is much scientists do not know about what makes a virus transmissible — and much they must learn before they are able to prevent another flu pandemic.
Now, however, scientists at the Australian National University in Canberra have announced that, in 1998 and 1999, while trying to create a virus that would render mice infertile, they accidentally made a virus that cripples their immune systems and kills them.
Writer interviews computer scientist Peter G. Neumann, 68… Writer visits Amsterdam to meet the person who made the Kournikova virus… It turns out that the young man, whose sign-on was ONTHEFLY but whose name is protected under Dutch privacy laws, was a "skriptkiddy," somebody who makes a virus by following a recipe from a kit.
Dr. W. Ian Lipkin of Columbia University questioned the need for the research and rejected Dr. Fouchier's contention that making a virus transmissible in the laboratory proves that it can or will happen in nature.
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