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So, besides the irreversible nature of AGEs, the positive feedback loops between AGEs and RAGE-downstream pathways could make a vicious cycle, thus providing a mechanistic basis for understanding why there could exist the phenomenon of 'metabolic memory' in vascular complications in diabetes.
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"Fake News CNN made a vicious and purposeful mistake yesterday," Trump declared in a tweet, on Saturday morning.
Soon afterward, Senator Joseph McCarthy made a vicious attack on several members of the group, and its funding vanished.
Both sides were surprised, but the French and Indians quickly organized themselves and made a vicious onslaught against the British.
It makes a vicious circle where you get arrested and get fined, so then you have to do more sex work to pay for the fine.
It is estimated that a single infectious person who remains undetected and therefore untreated can infect between ten and fifteen people every year, making a vicious cycle of failing control efforts.
Given the facts that serum DPP-4 activity is largely associated with circulating DPP-4 levels [ 59, 107 ] and that 20% of incretins derived from gastrointestinal tract are still alive in the blood pool [ 108, 109 ], AGEs may impair the effects of incretins via induction of DPP-4, further augmenting the formation and accumulation of AG Es making a vicious cycle in poorly controlled diabetes.
Mechanical ventilation also consumes energy, and all the factors mentioned make for a vicious circle.
"To have made such a vicious and degrading film appears an aberration of judgement on someone's part.
That might make a virtuous circle turn vicious.
"Strangely, a sudden urge was planted in me to make a horror film about vicious beauty.
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