The phrase "make a great difference to" is correct and usable in written English.
You can use it to describe how a change or event has a significant impact. For example: Reducing the use of single-use plastics will make a great difference to the environment.
"It does make a great difference to what publishers call sales and what I call readers".
Still, some industries have been lobbying Washington on the assumption that the election will make a great difference to them.
If we were to make dramatic efforts now to get emergency relief to the people, by airdrops or convoys or whatever, it would make a great difference to their survival -- and incidentally to America's standing.
Visibility is probably one of the most important factors that make a great difference to the proposed four characteristic distance.
"The cook and his repertoire can make a great difference to your quality of life," he notes wryly.
"It would make a great difference to the way in which it was perceived around the world if we were able to lend in future".
It was felt that local authorities could make a greater difference to the health and wellbeing of their communities if the right expertise, powers and funding were based there rather than within a health service more focused on treatment than prevention of disease.
"That always makes a great difference to a game.
"It makes a great difference to us and certainly helps our ability to promote a movie".
I was passionate about it and I know that I made a great difference to the lives of those I worked with.
For sustained periods during the past century or two, capital went where it was supposed to, and made a great difference to the pattern of economic development.
