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Exact(7)
As the majority of validated mRNA-miRNA interactions usually takes place in the 3'UTR of a gene [31], we have analysed the 3'UTRs of the different SHOX splice variants for miRNA binding sites by the miRWalk prediction tool.
Therefore, the MirSNP database could cover majority of validated miRNA-related SNPs.
Our study captured the vast majority of validated tools currently available to measure experience of care from the patient perspective.
So far, the majority of validated P-deficiency-responsive miRNA target genes are transcription factors, and other target genes mainly encode for abiotic/biotic stress-responsive proteins and enzymes related to protein modification/degradation [ 25].
Therefore, whilst seeds in the 3'UTRs of genes make up the vast majority of validated target sites in the literature, this is largely the result of an early entrenched software bias rather than a biological requirement 83.
Notable, however, was the fact that the majority of validated calls were identified by two or more algorithms, suggesting that a merging approach may improve both the sensitivity and accuracy of somatic variant calling.
Similar(53)
For the majority of the validated markers, the direction of the SNP effects was the same in the discovery and Holstein validation data sets, although the magnitude of the estimated effects was generally reduced in the validation data set.
The majority of the validated leads, 18 of 24 (75%), are already approved for use in humans, thus, facilitating relatively rapid clinical translation of these findings.
The majority of the validated ORESTES (14) detected a single band in northen blots, which could indicate the presence of unique transcripts.
We chose MirSNP due to its high sensitivity in covering a majority of the validated miRNA-related SNPs when compared to other databases [31].
It has been recently demonstrated with the majority of miRNA-validated targets that miRNAs preferentially bind to 3'-UTR sites that do not have complex secondary structures and are located in accessible regions of the mRNA based on favourable thermodynamics.
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