While the majority of generated transformation products are likely benign, substantial conservation of structure in transformation products can imply conservation or even creation of bioactivity across multiple biological end points and thus incomplete mitigation of ecological risk.
Furthermore, the plant tissue culture phase employed in the vast majority of GM transformation procedures is known to bring about large numbers of random genome-wide mutations and even chromosomal rearrangements, a phenomenon known as "somaclonal variation" [14 16].
Glucuronide conjugation to the 5- and 7-hydroxy positions of flavopiridol by uridine diphosphate glucuronosyltransferase isoforms 1A1 and 1A9 (UGT1andand UGT1A9, respectively) accounts for the majority of metabolic transformation of flavopiridol [25], [26].
The pathogenesis of AML in patient #26 and #38 is consistent with previous reports which show that in a majority of cases, transformation to AML in patients with classical MPD occurs in a stem cell with a wild-type jak2 gene [29], [30].
The nodes involving the nectar-feeding subfamilies Glossophaginae and Lonchophyllinae were the best supported (Table 4 and Fig. 4), and had a majority of character transformations occurring in characters associated with the feeding apparatus.
In the majority of instances of transformation of another, the transformation is considered to be the result of evil magical powers, and most tales conclude with the disenchantment of the subject, his release from the evil power, and his return to his original form.
The majority of existing plant transformation vectors are quite large (typically 10 kb or more) and therefore may not amplify well using PCR.
The majority of the ϕ transformations are not known.
The vast majority of RS represent transformations to an activated B-cell type (ABC) diffuse large B-cell lymphoma (DLBCL) 90-955%) with a small proportion transforming to Hodgkin's lymphoma [ 6].
Although we did find a few cells expressing the N-terminal fluorescent-tagged Δ1-142 DAYSLEEPER fusion-protein, the majority of cells died after transformation indicative of the toxicity of this particular fusion protein.
