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Exact(5)
It is noteworthy that the incidence and severity of oral mucositis, like the majority of toxicities, is underreported.
However, with extended follow-up over a median of ∼6 months from the start of protocol treatment, we believe that the vast majority of toxicities were captured.
The majority of toxicities were grade 1 or 2. The most common treatment-related toxicities at the MTR (dose level 4) were diarrhoea (69%), fatigue (46%), nausea (31%), and anorexia (31%).
However, as the majority of toxicities are thought to be due to the slow glucuronidation of SN-38 49, 49, it was decided that the higher DNA damage levels induced using this metabolite would be more informative and more likely to detect interindividual differences than the lower levels detected following irinotecan exposure.
For higher dose levels, this was after at least one patient had completed 4 weeks of treatment; during this accelerated dose-escalation phase, the majority of toxicities above grade 1 in severity developed after the decision to dose escalate had been taken.
Similar(55)
The vast majority of toxicity studies and risk evaluations deal with single chemicals.
This group is further divided into Group IIIA where one chemical provides the majority of toxicity of the combined exposures (MCR is less than two) and Group IIIB where no one chemical dominates the toxicity of the exposures (MCR is greater than two).
The validity of these data may therefore be questioned, although the majority of toxicity results were in line with previous clinical studies of pemetrexed [ 6].
The majority of nonhaematological toxicities were mild.
Generally, the majority of hematological toxicities in both arms are Grade 1-2 and manageable.
The majority of symptomatic toxicities were amenable to supportive care including anti-emetic, anti-diarrheal, and topical agents.
Related(20)
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