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The majority of susceptibility loci for breast and other cancers have been detected using studies of predominantly European ancestry.
In such cases, correlation analysis of effect size of each SNP may be more powerful to determine whether two different subsets share the majority of susceptibility loci or not.
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A majority of the susceptibility genes identified in our study represented antioxidant defense enzymes.
Calculations based on these data have estimated an overall heritability of about 60% [ 2, 3], indicating that genetic factors account for the majority of population susceptibility to RA.
In support of this, a majority of CD susceptibility genes that have been identified, including NOD2 and ATG16L1, have known immune cell functions.
The vast majority of these susceptibility loci belong to pathways involved in immune responses or inflammation and were identified in other AIDs [ 3].
The high susceptibility seen in double heterozygotes, with one copy of each region, indicates that these two loci are responsible for the majority of the susceptibility in the BR strain.
The number of OA cases will also need to be expanded to provide the power to account for susceptibility differences between ethnic groups, between the two sexes and between different joints; without case sample sizes in the tens of thousands the vast majority of OA susceptibility alleles will go undetected.
These results are also consistent with previous observations that the vast majority of common susceptibility alleles for breast cancer are non-coding; even after deliberately selecting potentially associated nsSNPs, the confirmed associations appear to be markers for other, presumably non-coding, functional SNPs.
After all, the majority of obesity-susceptibility loci have been identified in GWAS meta-analyses of 30,000 to 124,000 individuals.
In summary, the condition n > 1 ensures that at least two recombination events are required to transform one susceptibility type into the majority of the other susceptibility types.
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