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Exact(17)
Recently, a number of studies using global methods have shown that the majority of splicing is co-transcriptional, yet not all published studies agree in their conclusions.
Interestingly, the majority of splicing factors that are alternatively spliced are not differentially expressed (80%).
In agreement with prior observations [28], [49], the majority of splicing factors with significant differential gene expression were up-regulated by activation.
We attempted to identify and quantify the majority of splicing variation within TCF7L2.
Mutation of splice donor sites was undertaken to prevent the majority of splicing within the vector genomic RNA.
The fact that the majority of splicing factors are involved in several cancer types suggests a genome-wide mechanism.
Similar(43)
Said differently, completely ab initio is impossible in the vast majority of splice sites in annotated circRNAs and linear transcripts.Availability: Two python scripts generating an equivalent junction sequence per junction are available at: https://github.com/salzmanlab/Equivalent-Junctions.Supplementary information: Supplementary data are available at Bioinformatics online.
The majority of splice mutations disrupt the native splice site through a base change within the invariant donor or acceptor dinucleotides (5).
Truncation of the ORF in the majority of splice variants (particularly MYB) does not necessarily exclude a functional role for these alternative variants.
The majority of splice variants in PML-RARA, E2A-PBX1, and TEL-AML1 were PML-RARA L-form (50%), E2A-PBX1 (I) (66.7%), and TEL- AML1ex2 (94.4%), respectively.
One other recently developed qPCR primer design software QuantPrime (14) also features gene-specific primer design (i.e. covering the majority of splice variants) as an option.
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