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The cytomorphology of these three entities has been scrutinized extensively by light microscopy; the majority of serous effusions are readily placed in one of the three categories based on astute assessment of cytological features and architecture of cell groupings.
GATA4 expression is absent in the majority of serous ovarian cancer, and GATA6 is also absent in many but also positive in some cases (Table 1).
The dataset GSE6822 (N = 74) [25] contains a majority of serous specimens (N = 46, 62%) and includes benign, borderline and invasive tumors.
In the present study, which focused exclusively on the serous subtype, all evaluable tumors expressed MHC class I. Similar results have been reported by others for serous EOC [59], suggesting the vast majority of serous tumors are MHC class I positive and have the capacity to present antigen to tumor-infiltrating CD8+ T cells.
Nuclear expression of the Wilm's tumor suppressor is found in OSE cells and in the majority of serous EOCs [ 39].
In our study-population, the majority of serous and endometrioid tumor tissues were PELP1 positive, whereas we observed a significantly reduced number of PELP1 expressing mucinous tumors (37.5%).
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It is important to note that the majority of the serous tumors on the left side show a distinct expression pattern that deviates from clear cell and mucinous tumors that are negative for the LPA-signature.
The majority of high grade serous carcinomas also show mutation and/or loss of functional p53 [7], [8], [8].
We identified 90 CpG sites (associated with 68 genes) with significantly subtype-specific methylation patterns, the majority of which distinguished serous from endometrioid tumors.
The majority of patients had serous ovarian cancer (79%).
For example, the majority of high-grade serous ovarian cancers (HGSCs) (which are included in type II epithelial ovarian cancers; responsible for the majority of all ovarian cancer mortality (Brown and Palmer, 2009)) originate outside the ovaries, spreading to the ovaries as they progress (Gilbert et al, 2012).
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