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However, both the procedure and the obtained results seem to indicate that the majority of retained introns in our study come from underspliced transcripts.
First, the majority of retained introns are subject to nonsense-mediated mRNA decay [ 26, 64], which tend to locate at the 3′ terminal of transcripts.
Duplicated genes in bacteria appear to be created mainly by small-scale gene duplication events, and the majority of retained duplicated genes occur as single genes, not duplicated operons [ 13].
Further, longer introns in general tend to have stronger splice sites; however, the latter trend becomes observable only for bona fide introns longer than 1500 nt [ 43], and thus should not influence the majority of retained introns studies here.
A recent study in men and bulls demonstrated that the vast majority of retained nucleosomes are located within distal intergenic regions and introns are associated with centromere repeats and retrotransposons, while 5′-UTRs, 3′-UTRs, TSSs, and TTSs were depleted from nucleosomes [ 15].
One of consequences of that is that the majority of retained introns studied here are unlikely to encode functional proteins, as only 3.3% of them are frame-preserving (this number is close to 4.6% in-frame retained introns observed in Arabidopsis [ 10]).
Similar(54)
As in the case of MFP, for NN and DGA, the majority of the retained matches were for compounds 1 – 13.
The majority of Treg retained expression of FoxP3pos after two cycles of expansion.
Moreover, the majority of glycoproteins retained on the GNA column were unique to one particular insect species and only a few glycoproteins were present in the five different glycoprotein sets.
Importantly, the majority of progeny retained the same mobilome as their parents.
The majority of studies retained did not apply any exclusion criteria to their population of interest for their analysis.
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