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For modeling the structure, the majority of restraints were obtained from the 8-Br-G6-modified self-complementary duplex because the equilibrium between two conformations of the unmodified duplex can influence NOE volumes and make the spectra complex with many overlaps.
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We also eliminated residues in regions in which there were either very few contact restraints, or the majority of the restraints were violated.
The majority of NOE restraints were measured from a sample in D2O and the NOEs in this dataset were well predicted (χ per restraint = 0.8).
In the folded states the majority of experimentally observed NMR NOE restraints are satisfied.
Inactivation of the ARF/p53 pathway is a critical event in the majority of human cancers, serving to lift restraints on oncogenic signaling [31].
In addition, although a higher proportion of restrained residents might seem more difficult for the nurses to remember as compared to a lower proportion, the nurses didn't show any hesitation when recalling the use of physical restraints as the majority of residents had been living there for a long period of time.
There were 17 different violated intraprotein restraints, with seven restraints being violated in the majority of structures.
The NYPD claims to have arrested roughly a dozen people, and while a majority of officers practised a noticeable degree of restraint, videos depict several confrontations involving heavy-handed police tactics.
She adds that "budget is the biggest restraint for the majority of people looking to make it in the fashion industry, but by doing your own styling, photography, editing, graphic design, pattern cutting etc. you are able to build a brand whilst retaining 100 per cent of your creative vision".
As J. S. Mill puts it, " cases exist in which almost the only restraint upon a majority of knaves consists in their involuntary respect for the opinion of an honest minority" (Mill 1861, 362).
All kinds of restraints were coming off.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com