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Gating on all combinations of T cell subtypes expressing one or more of the cytokines IFN-γ/IL-2/TNF-α clearly demonstrated that the majority of proliferating CD4 cells were cytokine expressing, in contrast to the non-cytokine producing CD4 T cell population, which did not proliferate (IFN-γ−IL-2−TNF-α−, Fig. 7D).

The majority of proliferating cells were pS6-immunoreactive except for those surrounding the central canal.

The majority of proliferating cells in the adult mammary gland are ER/PR negative [ 18, 25], suggesting a paracrine mechanism for hormone-induced proliferation.

Interestingly, previous studies have demonstrated that CD56bright NK cells constitute the majority of proliferating lymphocytes after 6 days stimulation of PBMCs with extracellular BCG 29, 30.

At E18.5, the VZ/SVZ of control forebrains exhibited a significant reduction of the thickness, and the vast majority of proliferating cells were clustered in the first three bins of the VZ.

As the buccal mucosa is a stratified epithelium with the majority of proliferating cells being present in the layers at, or near to, the BM (cf Figure 2), standard exfoliative techniques, which do not sample from these deeper layers, may limit the usefulness of this approach for assessing PD end points based on inhibition of proliferation.

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This indicates that N2 medium induces both salivary gland epithelium and mesenchyme to form spheres, and a majority of cells proliferating in N2 medium were epithelial cells.

Immunocytochemical analyses of cardiac TnI confirmed a uniform staining of proliferating mononucleated myoblasts and a vast majority of myotubes.

Genetic evidence indicates that the majority of squamous HNC originate from hyperplastic fields characterized by higher numbers of proliferating cells and clonal selection (Rubin 2011; Tabor et al. 2002).

Only a small number of the myonuclei of proliferating mononucleated cells were found to express myogenin, whereas the majority of the nuclei were myogenin positive in the multinucleated differentiated cells confirming their more advanced differentiation level.

Quantitation of the phospho-histone H3 staining showed a virtual absence of proliferating cells at late time points indicating stem cell senescence in the majority of crypts (Fig 4A).

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