The vast majority of "Clinical progression events" were due to increase of at least 4 AUA points from baseline.
It was found that, in the majority of cases, progression to end-stage renal disease occurred despite discontinuation of Chinese herbal remedies [ 38], and invasive urothelial carcinoma after exposure to Chinese herbal remedies containing AAs may occur even without severe renal failure [ 43].
This is of clinical relevance, inasmuch as the majority of disease progressions take place in these patients in visceral sites due to the haematogenous spreading of metastatic cells.
In the majority of patients, disease progression occurs following cessation of treatment with an HSP90 inhibitor [ 8].
Also, in the majority of patients disease progression may be altered due to more or less suitable immunosuppressive protocol treatments and therapeutic approaches.
Our results apply to CIS, which represent the vast majority of cases, and progression to invasive cancer may require additional, as yet unknown, risk factors.
In the majority of cancers, tumor progression occurs even in the presence of immune cells, such as cytotoxic CD8+ T cells and natural killer cells [ 35], that are frequently associated with cytotoxic effector functions.
17 The majority of joint damage progression in the current study was observed within the first 6 months, with further damage almost entirely prevented thereafter; the reasons for this are unknown.
Even in patients with low-risk melanomas <1.0 mm (846 of 1270), the majority of those with progression, that is, 21 of 32 (65.6%, χ=63.9; df=1; P<0.001), and those who died, that is, 11 of 15 (73.3%, χ=39.0; df=1; P<0.001), showed statistically significant MT overexpression in their primary melanoma.
Even after this decade of EDIC follow-up, and as observed at the conclusion of the DCCT and at EDIC year 4, the HbA1c difference between the intervention groups during DCCT explained the majority of the retinopathy progression benefit (97.7% at EDIC year 4, 89.3% at EDIC year 10) (8).
