Sentence examples for majority of parp from inspiring English sources

PARP1 is responsible for the majority of PARP activity in the cell [12].

In the clinical setting, the majority of PARP inhibitor combination trials have focused upon combining PARP inhibitors with standard of care therapies [reviewed in (Lord & Ashworth, 2012)].

On the basis of structural information available for the catalytic domains of PARP1 and PARP2 co-crystallized with NAD+ or certain PARP inhibitors, it became clear that the majority of PARP inhibitors mimic the nicotinamide moiety of NAD+and bind to the donor site within the catalytic domain [ 120- 122].

Some animals with accelerated evolution (e.g. nematode Caenorhabditis elegans and fruit fly possess only three and two PARPs, respectively) have lost the majority of PARPs present in common metazoan ancestor.

In accordance with this result, the majority of the PARP molecules in the U-373MG cells co-infected with Adv-p53, Adv-APAF1 and Adv-Casp9, was the cleaved form (p85), a substrate on which caspase-3 acts.

Majority of bacterial PARPs are most similar to the DNA repair-specific Clade 1 PARP homologues.

Duplication events that preceded the origin of the majority of recent human PARPs likely occurred before the chordate radiation.

As the majority of reported studies on human PARP-1 polymorphisms and activity have been conducted using lymphocytes, half of our panel were of leukaemic/lymphatic origin and included the immortalised human bone marrow stromal cells.

Loss of SRO1 causes only minor defects; however rcd1; sro1 double mutants are severely affected with a majority of individuals dying during embryogenesis [ 65, 69], indicating that this clade of PARP proteins has essential functions in land plants.

NTN in PARP-1-deficient mice demonstrates that PARP-1 is responsible for the majority of poly (ADP-ribosyl -ation in the nephritic kidney, ADP-ribosyl -ationADP-ribosyl -atione used as a measure of PARP-1 actinathenephritic

The PARP family consists of 17 family members, but the majority of poly-ADP-ribose is synthesized by PARP1 [24] and some PARP family members remain poorly characterized experimentally [22].