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The study was conducted in a population in northern Tanzania where the vast majority of parasite carriage occurs below the microscopic threshold for detection [ 4].
Compared to wild caught fish from the same area infection [ 34] intensities here were much higher in the majority of parasite species observed in this study.
While facultative for the majority of parasite pathogens, gametogenesis and fertilization are obligate steps of the Plasmodium life cycle (Heitman, 2010), consequently, disrupting either process prevents infection of new hosts.
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Artemisinin would land a brutal shock-and-awe strike that destroyed the majority of parasites, mefloquine would mop up the survivors.
The culture was gassed (5% CO2, 2% O2, and 93% N2) and incubated at 37°C at 85 rpm until the majority of parasites matured to schizonts.
The majority of parasites in exotic species (67%) are native parasites implying that exotic species commonly have the potential to cause parasite spill-back to native hosts, with effects at both the host individual and population scale [55].
Remarkably, parasite growth occurred in a synchronous fashion (Figure 4C and Figure S2), with the vast majority of parasites in peripheral blood being at the same stage at a given time (Figure 5).
The results of the study suggest that var-gene switching, at least for a subset of genes, involves a programmed process where a large majority of parasites switch to transcribe a single member of the var-gene family, PFL0030c or var2csa, which however seems to be translationally repressed.
However, treatment with 20 μM miltefosine led to a loss of Δ Ψm in the majority of parasites (Fig. 5a).
Following treatment with 10 μM staurosporine for 48 h, the majority of parasites retained the Δ Ψm as also observed in mock-treated parasites.
The sample was centrifuged at 200 × g for 10 min to pellet the majority of the blood cells, while leaving the majority of parasites in the supernatant.
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