We found the majority of mutations to reside in the shared clonal cluster for all cases.
In the vast majority of mutations, there is no functional effect on the influenza virus itself.
Moreover, the majority of mutations have no negative impact on stereoselectivity.
The majority of mutations result in loss of subunit protein expression, implicating mSWI/SNF subunits as tumor suppressors.
The vast majority of mutations in the panel result in amino acid changes, but some of the mutations occur within promoter regions.
One possible explanation is that the majority of mutations detected in tumor and plasma were subclonal and restricted to spatially separated tumor regions.
The majority of mutations with NC above 0.1 were found within all six libraries from the same DNA sample prepared on four separate occasions (Supplementary Figs. 4 7).
The VWF gene is a large gene containing 52 exons; except for type 2 VWD, the majority of mutations causing VWD are not localized to specific exons.
We found that the majority of mutations in the AI-resistant tumour were shared with their paired pre-AI sample, but almost half of the pairs showed at least one private mutation.
Additionally, the majority of mutations are heterozygous, indicating that both genes most likely function as haploinsufficient tumor suppressors.
The majority of mutations in our study were located in exon 4 and 3, followed by exon 18 and 22.
