Sentence examples for majority of mutation from inspiring English sources

The fact that the large majority of mutation carriers underwent endoscopic surveillance is more reassuring.

The majority of mutation carriers in the study carried either BRCA1 185delAG (32 out of 42 [76%] of all BRCA1 mutation carriers) or BRCA2 6174delT.

Although these psychological symptoms decline over time for the majority of mutation carriers [ 19- 22], significant psychological distress can persist for others [ 22, 23].

Finally, it is interesting to note that like the mutation positive cases, the majority of mutation negative patients had also been referred by geneticists within clinical genetics departments including six from members of the ESDN panel.

There is evidence that BRCA1-associated breast cancers are more aggressive [ 36, 37], and that adjuvant chemotherapy should be considered in the majority of mutation positive women, even those with small, node negative breast cancers.

Prophylactic mastectomy remains unacceptable to the majority of mutation carriers for a variety of reasons, including the prospect of mutilating surgery, loss of sensation, and breast cancer not being totally preventable (Warner, 2004).

Again, the majority of mutations were localized to exons 5-8, the mutational hot-spot for p53 found in most cancers.

Moreover, the majority of mutations have no negative impact on stereoselectivity.

The majority of mutations occur at R882 (60%–64%), and almost all are heterozygous (Ley et al., 2010; Thol et al., 2011a).

Additionally, the majority of mutations are heterozygous, indicating that both genes most likely function as haploinsufficient tumor suppressors.

The majority of mutations and deletions are homozygous, though loss of only one allele may be sufficient to drive tumorigenesis.