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Our three laboratories have contributed the majority of mutated genes, 6841 mutations in 6013 genes.
For several genes, a limited number of recurrent mutations made up the majority of mutated alleles.
We further identified three highly prevalent USP8 mutations, which account for the vast majority of mutated cases (77.61%).
Furthermore, jury is still out on the outcomes and effectiveness of stem cell therapy and bone marrow transplant that are used for treating myelocytic leukemia on patients pre-treated with whole body radiation to destroy majority of mutated blood cells.
The majority of mutated tumors were secondary GBMs (16 in 18, 89.9%).
On the other hand, the majority of mutated GBMs in our cohort are probably secondary glioblastomas.
Similar(52)
Similarly, for B cell populations that show lower levels of mutation, e.g., splenic B-1a from 2 month old animals and peritoneal B-1a from 2 6 month old animals, the majority of both mutated and non-mutated sequences are either IgM or IgD and thus rarely class-switched.
The majority of TP53 mutated tumors harbor missense mutations in this gene, correlated with p53 accumulation.
The majority of these mutated genes are transcription factors, such as PAX6, FOXC1, PITX2, PITX3, FOXE3 and AP2α (2).
In our dataset, the low level of polymorphism along any given branch of the tree (the majority of inferred mutated genes contain only a single polymorphism specific to the pathotype branch) does not provide enough power to estimate selective constraints accurately in a pathotype-specific manner [ 49].
The majority of mutations of Gs-alpha simultaffectly affect other GNAS-derived transcripts that share the same exons, but the role of these additional mutated transcripts in human disease, if any, remains to be clarified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com