Sentence examples for majority of mutagenicity from inspiring English sources

However, these studies show that the majority of mutagenicity is usually associated with moderately polar/highly polar classes of compounds that tend to contain nitroaromatic compounds, aromatic amines, and aromatic ketones.

There is an ongoing debate regarding the genotoxic status of OTA, much of it related to the negative results obtained from the majority of microbial mutagenicity assays, including the traditional Ames test (NTP 1989; Kuiper-Goodman and Scott 1989), and because it is at best moderately genotoxic in in vitro or in vivo mammalian test systems (Brambilla and Martelli 2004).

Genetic toxicology Role of mutagenicity in fiber-induced carcinogenicity Is there a mutagenic MOA? Mutagenicity/carcinogenicity at low doses.

Kazius et al. provided an analysis of mutagenicity data correlating chemical substructures to mutagenicity [21, 27, 28].

The principle of mutagenicity through reaction of DNA with electrophiles has been especially useful in rationalizing and deriving "toxicophores," substructures that are strongly associated with mutagenicity [21, 22].

In addition, toxic compounds were filtered out using a categorical SVM model for prediction of mutagenicity trained on Ames-test mutagenicity data (5-fold ROC score: 0.8948).

In the following sections this paradigm is implemented for modeling the well-studied endpoint of mutagenicity.

Table 2 Confusion matrix of mutagenicity integrated model on the training set (3367 chemical compounds).

In the context of mutagenicity we also wish to limit the enumerations to connected combinations only.

This simple descriptor alone can provide a useful prediction of mutagenicity [3, 67, 68].

Average recovery of mutagenicity was about 60%.