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As shown in Fig. 3A, the vast majority of modulated genes at 24 hours were also regulated at 48 hours.
From the numbers of up- versus downregulated (170 versus 462) transcripts it is easily seen that the bacteria upregulates a selection of stress response genes, while the majority of modulated genes are downregulated to focus on the repair process.
In both species, the majority of modulated transcripts were upregulated.
However, the majority of modulated genes were cell-cycle specific.
In both lines, the majority of modulated transcripts was up-regulated, although in the susceptible genotype a higher percentage of pathogen-induced genes was detected (~73% vs. ~83% for CO441 and CO354, respectively).
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Instead the vast majority of differentially modulated pathways were equally distributed between the specific exposure conditions.
The majority of the modulated miRNAs were found to target the transcriptional machinery, and mRNAs related to metabolism and antimicrobial responses (Additional files 5 and 6: Tables S1 and S2).
Overall, our findings revealed that the majority of the differentially modulated proteins overlap between HCV mono- and HIV-1/HCV co-infected PBMCs.
Neurons demonstrating rate tuning make up the majority of neurons that respond to modulated sounds in-non primary auditory areas and are frequently tuned to rates at 64 Hz and above.
However, analyses of modulated gene regulation typically focus on how expression levels of modulators affect regulating strength, instead of the causal relationships, between modulated genes.
We recorded at that level to examine whether Atoh1 neurons were strongly respiratory-modulated, like the majority of neurons within the ventrolateral medulla in preBötC-containing slices.
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