The majority of mechanisms proposed for neurotoxicant-induced cellular damage converge on mitochondrial dysfunction and energy deprivation [ 7].
This inflammatory reaction is particularly relevant for sepsis in which the majority of mechanisms of immune-mediated heart and kidney tissue injury have been described in detail [ 131- 134].
However, the majority of mechanisms summarized in the present review could affect the risk of any kind of cancer, with some additional mechanisms applying to sex-hormone-dependent cancers.
Although the anatomical differences between the rodent and human brain will always pose a caveat for preclinical research, rodent-based experiments are expected to form the majority of mechanism-of-action and proof-of-concept studies that can then be further validated in large-animal species.
Fault plane solutions, both from first motion polarities and from waveform inversion, show a majority of thrust mechanisms followed by strike-slip mechanisms.
The majority of reaction mechanisms reported so far is based on the Lewis acidity of a given metal ion.
However, in contrast to the majority of these mechanisms, we are able to encompass the transient, dissipative nature of a braking process.
The majority of these mechanisms are the same as those found in tumor cells: antigenic loss, lack of expression of classic HLA-I molecules, production of immunosuppressive cytokines, induction of lack of expression of co-stimulatory molecules in antigen presenting cells, and induction of apoptosis in infiltrating lymphocytes, with activation of a type Th2 regulatory lymphocyte response.
Interactions between proteins drive the majority of cellular mechanisms, including signal transduction, metabolism, and senescence, among others.
The majority of these mechanisms include host factors as methylation [ 47], deletions [ 48], silencing by RNA interference [ 49] or random mutations, excisions and purifying selection [ 50].
While the majority of homeostatic mechanisms have been studied following complete pharmacological blockade of spikes or AMPAR-mediated excitatory postsynaptic currents (EPSCs), we decided to examine long-term effects of neuromodulation on firing properties of the network.
