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However, it is largely recognized that the great majority of joints do not exhibit such idealized behaviour transmitting bending moments with non-negligible rotations.
The only sheep with significant degenerative joint disease was the Finn-Dorset clone 2262, with moderate to severe osteophytosis (scoring 2 3 on the modified scale of Kellgren and Lawrence40) of the majority of joints (Figs 5 and 6a).
Active rheumatoid arthritis (RA) is characterized by continuous progression of the inflammatory process, eventually affecting the majority of joints.
In contrast, the majority of joints from mice injected with UC-MSCs had normal morphology with a smooth articulation cartilage surface, and an absence of inflammatory cell infiltrate and pannus formation.
It is apparent that change, either positive or negative, was a very rare feature in this trial; the great majority of joints was scored as unchanged; between 1.3% and 5.8% of the joints were identified as changed readings.
However, the CIA mice exhibited moderate to severe inflammation, synovial hyperplasia, pannus formation, and bone erosions (individual histology scores of 2 to 3) in the majority of joints examined.
Similar(51)
As previously reported, the majority of joint damage observed in rituximab-treated patients occurred between baseline and 24 weeks.
> In the great majority of joint examined, a high degree of intra-articular PD signal may be found at the level of synovial proliferation (Fig. 1g, h).
Another sub-analysis of the ATAC trial showed that the majority of joint symptoms occur within 24 months of initiating treatment [ 46].
However, the opportunity to develop a common vision and partnership for gender has been missed in the majority of joint gender programmes, as part of the underinvestment in design.
17 The majority of joint damage progression in the current study was observed within the first 6 months, with further damage almost entirely prevented thereafter; the reasons for this are unknown.
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