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GABAA receptors are ligand-gated Cl− ion channels that mediate fast synaptic transmission at the vast majority of inhibitory synapses in the mammalian brain.
One additional limitation comes from the fact that in this study pyramidal neurons were pharmacologically isolated and the majority of inhibitory (glycine/GABAA) and excitatory (AMPA/NMDA) inputs were blocked by an inhibitory cocktail (see Methods).
By the criterion that they have conserved P1/P1'sites, the majority of inhibitory serpins in the Drosophilid genomes are non-redundant.
As shown in Fig. 2B, the majority of promotive genes correlated negatively with CDKN2B, whereas the majority of inhibitory genes correlated positively with CDKN2B.
The majority of inhibitory synaptic contacts established by BIns onto the L4 spiny neurons are at a mean dendritic distance to the soma of 66 ± 32 µm.
Furthermore, it is possible to understand the importance of Arg119 in catalytic binding-site formation, since the majority of inhibitory molecules interact with this residue.
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As the majority of the inhibitory materials are usually associated with the hemicellulose rich, water soluble component, this fraction was supplemented with glucose to simulate high solids, un-detoxified substrate to see if a high gravity/high cell consistency approach might better cope with inhibition.
Because β2-containing GABAA receptors mediate the majority of CNS inhibitory neurotransmissions, the derived alleles would increase the overall activities of CNS inhibition by increasing total β2-expression.
The majority of Drosophilid inhibitory serpin orthologues appear to represent non-redundant genetic functions, with strong constraints on the P1/P1'sites.
Dlx1/2-I12b-Cre Dlx1/2-I12b-Cre Dlx1/2-I12b-Creexpressesy of GABAergiCrenhibitorecombinase including PV-, somathetatin-, neuropeptide Y- and calretinin-positive cells (20).
The majority of these inhibitory factors are components of CNS myelin and the glial scar (e.g., Nogo, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp), chondroitin-sulfate proteoglycans (CSPGs), repulsive guidance molecule, and so on).
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