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This phase encompasses the vast majority of genomic research, including agnostic genome-wide association studies (GWAS) and candidate gene approaches.
In some cases, only a few repeat families account for the majority of genomic DNA (in the human genome, e.g., the family of Alu repeat elements cover ∼11% of the genome, Rowold and Herrara 2000); in other large genomes, no prominent repeat families are found, but many low redundant repeat classes account for the majority of genomic DNA (Cavallini et al. 2010).
It shows that the vast majority of genomic sequences (>99%) in all the genomes examined here exhibit random characteristics, and that there exists only a tiny fraction of the ORFs that do not conform to the random model.
Abstaining from a priori specification of candidate targets of selection, the genome-wide scan interrogates the majority of genomic regions without reference to their potential biological function although a posteriori interpretation and follow-up experimentation may lead to bias and false conclusions (Thornton and Jensen 2007; Pavlidis, Jensen, et al. 2012).
However, the majority of genomic data is still biased towards two major groups in the Ecdysozoa, nematodes and arthropods, and we need genomic information from further ecdysozoan phyla (such as priapulids) to enable us to draw this conclusion with even greater confidence.
However, their time, cost and labour-intensive nature limits their broad utility; thus, the functional importance of the majority of genomic aberrations in cancer remains unknown.
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To date, the majority of genomic-based biomarker radiation studies have focused on photon radiation.
The majority of the genomic copies found in the tef genome are delta prolamins including one expressed in our transcriptome studies (CL17177Contig1).
This is obviously a major obstacle in the evaluation of the majority of the genomic variability.
The majority of comparative genomic studies suggest that less than 15% of the genome is functional according to the evolutionary conservation criterion (Smith et al. 2004; Meader et al. 2010; Ponting and Hardison 2011), with the most comprehensive study to date suggesting a value of approximately 5% (Lindblad-Toh et al. 2011).
The researchers also found that the vast majority of these genomic regions are transcribed into lincRNAs, and that these are conserved across mammals.
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