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Furthermore, previous studies regarding RNA editing in development analyzed only editing sites within protein-coding regions and did not address the vast majority of editing events which occur within non-coding regions.
In particular, we focused on editing targets within the primate-specific Alu repeats which constitute the vast majority of editing sites in the human genome.
A majority of editing events involves codon changes from NCN to NUN (Ser, Pro, Thr, Ala → Phe, Leu, Ile, Met, Val) with editing at 2nd positions.
The consequences of an A-to-I editing event range from the trivial to the critically important, and the cellular functions of the majority of editing events are still unknown [ 5].
From analysis of protein-coding genes in several dinoflagellates, Lin et al [ 19] noted that the majority of editing events are to either a C or G, thus generating a net reduction in A+U content from the bias of ~70% for the coding sequences.
The density and types of edits are shown for the protein-coding genes in table 2. Consistent with RNA editing in other dinoflagellate mtDNA transcripts (Lin et al. 2008), the majority of editing types in Hematodinium sp. are A to G, most editing affects the first and second codon positions, and most result in an encoded amino acid change.
Similar(52)
These examples are exceptional cases that demonstrate the functional importance of RNA editing; for the majority of RNA editing events in organelles, however, the functional importance has not been specifically elucidated.
The majority (> 90%) of editing events occurred in introns and 3′ UTRs, and all observed editing was consistent with promiscuous editing, which occurs in long dsRNA (average of 123 positions targeted per region, see Supplementary Table S4).
The site's founder maintains however that the "majority" of edits are useful, and that he does still take a hands-on role himself.
Volunteers who make 100 or more edits a month now account for a majority of edits, and those who make 1,000 or more account for a quarter, according to Ed H. Chi, a researcher at the Palo Alto Research Center in California.
The problem is that Picnik is currently the only way to do that majority of edits on Flickr.
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CEO of Professional Science Editing for Scientists @ prosciediting.com