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The majority of downregulated genes were related to transcription, signal transduction, stress, host immune response, and proliferation.
Also the vast majority of downregulated genes from the entire set is found only in the larvae, including ndrg1l, the most strongly downregulated gene in the entire set.
The largest group of upregulated genes (53) constitutes the "larvae only" group, while the "larvae down" group contains the vast majority of downregulated genes (24).
The majority of downregulated tumor-suppressing miRNAs in HCC and their involvements with cellular processes are listed in Table 1.
We conclude from our results that in normal cells the majority of downregulated kinases following geldanamycin treatment is driven by indirect, non Hsp90-dependent mechanisms of degradation.
By contrast, the majority of downregulated genes in the SR treatment had protein metabolism (6), carbohydrate metabolism (5) and energy metabolism (7) functions.
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The majority of the downregulated genes encode components of the oxidative phosphorylation machinery.
The majority of the downregulated genes were associated with metabolism, transport and regulation of muscle development.
The majority of the downregulated genes were associated with regulation of metabolism, myogenesis, or regulation of muscle development and transport (Fig. 3).
Similar to the proteomics data, the majority of the downregulated genes were involved in energy metabolism, whereas upregulated genes were related to oxidative stress (Fig. 3A).
The majority of the downregulated genes are GC-specific and are essential for mitotic and meiotic progression of spermatogenesis, including Stra8, Dazl and members of the DM (dsx and map-3) gene family.
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